Links between Pyk2 and Map Kinases
| PAG Title | Links between Pyk2 and Map Kinases |
| PAG ID | WIG000414 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatates the JNK cascade, starting with PAK follwed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. |
| Species | Homo sapiens |
| nCoCo Score | 4,254 |
| Base PAG ID | WIG000414 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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